Microscopy has been at the core of cell biology research ever since the coining of the term ‘cell’ by Robert Hooke in the 17th Century1. For many years, it has been possible to gain insight into ‘steady-state’ cellular function from the analysis of fixed samples, but it is only relatively recently that imaging of living cells has become a widely used tool to support biochemical and electron microscopy studies. Membrane traffic research, which by its very nature is a highly dynamics process, has benefited hugely from the ability to image specific processes in living cells and tissues.

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