The imaging of live cells using light microscopy has come a long way from the early days of phase contrast. There have been many exciting developments in technology that now deliver live-cell images that previously would not have been thought possible. The study of dynamic processes right down to the molecular level as they happen in living cells is now common practice in the drive to understand cell function. So what has happened over the past 50 years to make live-cell imaging so much more accessible today?

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