The pathways of central metabolism provide the metabolic connections between the catabolic (degradative) and anabolic (biosynthetic) routes in all living organisms. In hyperthermophilic Archaea, we have discovered a promiscuous central metabolic pathway that catabolizes a variety of sugars using a single set of enzymes. This article explores the structural basis of this promiscuity in enzymes that have to maintain their integrity at temperatures approaching 100°C.
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Feature| February 01 2005
Promiscuity in the Archaea: The enzymology of their metabolic pathways
Biochem (Lond) (2005) 27 (1): 17–21.
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Michael J. Danson, David W. Hough; Promiscuity in the Archaea: The enzymology of their metabolic pathways. Biochem (Lond) 1 February 2005; 27 (1): 17–21. doi: https://doi.org/10.1042/BIO02701017
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