Allosteric ribozymes combine the features of ligand-binding aptamers with the catalytic activity of ribozymes and can be generated by rational design or diverse selection strategies. Their activity can be controlled by different types of effectors, ranging from small molecules to oligonucleotides and proteins. This direct coupling of molecular recognition to signal generation in real time allows the generation of versatile reporters that can be applied to report molecular interactions.

This content is only available as a PDF.