I first met my Yale colleagues Joan Steitz and Tom Steitz while I was postdoctoral fellow at the University of Colorado working on the group I intron splicing mechanism with Thomas Cech. Cech's discovery of the RNA self-splicing group I intron in 1981 provided the first demonstration that not all enzymes are proteins. The Steitz's, famous for their work in pre-mRNA splicing and X-ray structure determination, respectively, spent a sabbatical leave in Colorado from 1992 to 1993, where they enjoyed the high quality of the RNAfocused science that was present there. It was a scientific bonus for me to have both of them attend the weekly Cech laboratory group meetings and to regularly bump into them in the lunchroom.

This content is only available as a PDF.