For a scientist, using the electron microscope can be a life-altering experience. One sits in the dark, usually alone, looking for answers to particular puzzles. Where is this immuno-tagged protein located? Why is it in this place, in this cell, in this particular site? Wait a minute! What is this unusual structure? Why does it have this strange shape? What is this density inside? Why does it seem to interact with the Golgi body?

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