To a generation of partygoers, Ecstasy [3,4methylenedioxymethamphetamine (MDMA)] represents one of the safest illegal drugs available and, superficially, evidence supports this notion. Compared with other recreational drugs, there have been relatively few Ecstasyrelated deaths and there is little direct evidence for shortterm neurotoxicity at recreational doses. However, Ecstasy causes 5hydroxytryptamine (5HT) nerveterminal damage in rats, mice and monkeys, and, in several studies, the damage is irreversible.

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