Water is thought of as the universal solvent for biological macromolecules, and its interaction with the different amino acid side chains of proteins determines their folding. Only a small proportion of the water associated with enzymes is tightly bound, but this can play crucial roles in determining the rates and specificities of reactions. Water itself is a relatively poor nucleophile, and enzymes can employ different strategies to facilitate hydrolytic reactions.
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Feature| August 01 2008
Enzyme action: lock up your waters?: Water and active sites
Biochem (Lond) (2008) 30 (4): 4–9.
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Adrian J. Lapthorn, Nicholas C. Price; Enzyme action: lock up your waters?: Water and active sites. Biochem (Lond) 1 August 2008; 30 (4): 4–9. doi: https://doi.org/10.1042/BIO03004004
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