Neurodegenerative disorders are characterized pathologically by insoluble protein aggregates in the neurons of affected brain regions. A common theme in neurodegenerative disease which has emerged is that mutations in the genes encoding the abnormally deposited protein cause autosomal-dominant inherited forms of disease. More recently, it has become apparent that common genetic variance at the same loci that cause Mendelian disease predispose risk to sporadic disease, generally by altering the expression levels of wild-type protein. The microtubule-associated protein tau (MAPT) is a classical example of this principle, and in this article, we discuss the biology and genetics of MAPT in disease, and compare and contrast MAPT with other loci implicated in neurodegeneration.
Skip Nav Destination
Feature| April 01 2010
All MAPT out?: Well-travelled pathways into neurodegeneration
Selina Wray ;
Biochem (Lond) (2010) 32 (2): 14–17.
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
Selina Wray, John Hardy; All MAPT out?: Well-travelled pathways into neurodegeneration. Biochem (Lond) 1 April 2010; 32 (2): 14–17. doi: https://doi.org/10.1042/BIO03202014
Download citation file: