In the mid-1960s, two unusual genetic determinants were discovered in the yeast Saccharomyces cerevisiae. In genetic crosses, these determinants, called [PSI+] and [URE3] respectively, were found not to be inherited according to Mendel's laws. Little did the researchers realize at the time that the non-Mendelian elements they had stumbled upon were in fact two different yeast prions – although definitive evidence of this only emerged some 30 years later1.
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Feature| October 01 2010
Yeast prions as epigenetic determinants
Biochem (Lond) (2010) 32 (5): 30–33.
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Wesley R. Naeimi, Mick F. Tuite; Yeast prions as epigenetic determinants. Biochem (Lond) 1 October 2010; 32 (5): 30–33. doi: https://doi.org/10.1042/BIO03205030
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