Over the last 20 years, the pharmaceutical industry has seen a decrease in discovery and success based on computational and combinatorial chemistry, and an increase in base costs imposed by increasing regulatory requirements and a higher rate of failures during the development process1. Couple this to the potential of structural, hence intellectual property overlap between libraries of synthetic compounds and the need for low-cost, scalable and chemically unique new scaffolds, the pharmaceutical industry is starting to re-evaluate the potential of natural products to provide the industry with new drug leads.
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Feature| February 01 2012
The ocean pharmacy: A treasure chest of new drug leads
Andrew Mearns Spragg ;
Biochem (Lond) (2012) 34 (1): 16–21.
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Andrew Mearns Spragg, Simon G. Best; The ocean pharmacy: A treasure chest of new drug leads. Biochem (Lond) 1 February 2012; 34 (1): 16–21. doi: https://doi.org/10.1042/BIO03401016
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