Imagine you are a scientist and receive an email from a patient inquiring whether carrying a particular mutation is going to affect their offspring. This may sound unrealistic, yet this is the sort of thing that will happen increasingly as sometimes even doctors know very little about the role of specific genetic variants found in patients. As genetic testing becomes more affordable, for many people, finding out the exact sequence and alterations in their DNA could provide useful information for disease diagnosis, prognosis and treatment. However, knowing just the DNA sequence is not the whole story, as there is another layer of complexity added by a group of molecules called epigenetic regulators.

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