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in A revolution in sight: using induced pluripotent stem cells to investigate diseases of the retinal pigment epithelium
> The Biochemist
Published: 17 November 2023
Figure 1 Retinal pigmented epithelium. (a) The polarized retinal pigment epithelium interacts with the outer segments of the photoreceptor cells and (b) performs crucial roles to maintain the retina (based on Strauss, 2005; designed using Servicer Medical ART). More about this image found in Retinal pigmented epithelium. (a) The polarized retinal pigment epithelium ...
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in A revolution in sight: using induced pluripotent stem cells to investigate diseases of the retinal pigment epithelium
> The Biochemist
Published: 17 November 2023
Figure 2 Production of RPE from IPSCs. (a) Patient-derived IPSCs cells grow as distinct colonies. (b) Spontaneous differentiation of IPSCs into pigmented RPE patches. (c) Pigmented patches can be isolated, dissociated and plated to form pigmented RPE monolayers in culture. (d) A cross-section thro... More about this image found in Production of RPE from IPSCs. (a) Patient-derived IPSCs cells grow as disti...
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in A revolution in sight: using induced pluripotent stem cells to investigate diseases of the retinal pigment epithelium
> The Biochemist
Published: 17 November 2023
Figure 3 RPE cells can be produced from patient-derived IPSCs to help understand macular disease and test new therapeutics. (Image created with BioRender.com). More about this image found in RPE cells can be produced from patient-derived IPSCs to help understand mac...
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Published: 31 October 2023
Figure 1 Lori Jones of Bio-Sheen Services demonstrates forensic cleaning technique. Lori and Jeff Jones conduct training courses for new operators to learn from their decades of experience in the business. Photo: J. Jones. More about this image found in Lori Jones of Bio-Sheen Services demonstrates forensic cleaning technique. ...
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Published: 31 October 2023
Figure 2 Calliphoridae (blow flies) oviposit in decomposing bodies, using them as incubators for their young larvae before they migrate away to pupate and become adult flies. Here, a mass of larvae (a); pupae on vinyl flooring at the site of an unattended death (b); emerged adult flies on a horizo... More about this image found in Calliphoridae (blow flies) oviposit in decomposing bodies, using them as in...
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Published: 31 October 2023
Figure 3 Ceramic tiles stained with bovine blood are used to train operators in proper forensic cleaning techniques. Photo: J. DeBruyn. More about this image found in Ceramic tiles stained with bovine blood are used to train operators in prop...
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Published: 27 October 2023
Figure 1 Action Centred Supervisory Leadership. More about this image found in Action Centred Supervisory Leadership.
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Published: 19 October 2023
Figure 1 Blow fly maggot masses on a pig carcass (G.S. Anderson) More about this image found in Blow fly maggot masses on a pig carcass (G.S. Anderson)
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Published: 19 October 2023
Figure 2 Pre-puparial third instar blow fly larvae leaving the food source in search of a suitable site in which to pupate. Note darkened crop area, which contains the DNA of the host (G.S. Anderson). More about this image found in Pre-puparial third instar blow fly larvae leaving the food source in search...
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in Empowering students with hearing impairment to pursue science careers in Kaduna State, Nigeria
> The Biochemist
Published: 19 October 2023
PEAN’s facilitator and a sign language interpreter giving a talk on science and science careers. More about this image found in PEAN’s facilitator and a sign language interpreter giving a talk on science...
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in Empowering students with hearing impairment to pursue science careers in Kaduna State, Nigeria
> The Biochemist
Published: 19 October 2023
PEAN’s facilitator leading the DNA origami activity. More about this image found in PEAN’s facilitator leading the DNA origami activity.
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in Empowering students with hearing impairment to pursue science careers in Kaduna State, Nigeria
> The Biochemist
Published: 19 October 2023
A cross-section of PEAN’s facilitators and staff and some of the students of KASSES. More about this image found in A cross-section of PEAN’s facilitators and staff and some of the students o...
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The Biochemist
Biochem (Lond) (2023) 45 (5): 24–28.
Published: 11 October 2023
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Published: 11 October 2023
Gummy bears soaked in different isotonic solutions overnight can be introduced through a visualiser to guide the explanation of isotonic solutions during a lecture. More about this image found in Gummy bears soaked in different isotonic solutions overnight can be introdu...
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Published: 11 October 2023
Emma’s cats (a) Peggy and (b) Peter as kittens help to introduce the complex topic of neural control of stepping in her lectures. More about this image found in Emma’s cats (a) Peggy and (b) Peter as kittens help to introduce the comple...
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Published: 11 October 2023
Emma’s creative approaches to teaching. (a) Emma highlighting different brain regions using a brain hat freely available from: https://ellenjmchenry.com/brain-hemisphere-hat. (b) Emma using a giant cuddly neuron to explain the process of nerve conduction in a first year lecture. More about this image found in Emma’s creative approaches to teaching. (a) Emma highlighting different bra...
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Published: 28 September 2023
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Published: 28 September 2023
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Published: 28 September 2023
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Published: 28 September 2023
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Published: 28 September 2023
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Published: 28 September 2023
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Published: 28 September 2023
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Published: 28 September 2023
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Published: 21 September 2023
Figure 1 Amino acid diversity encompassed by the genetic code. DNA triplets (codons) are shown in the form of a sun, from the inside to the outside. The encoded amino acids are shown towards the outside. The chemical structure of amino acids is included, along with a colour scheme that illustrates... More about this image found in Amino acid diversity encompassed by the genetic code. DNA triplets (codons)...
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Published: 21 September 2023
Figure 2 Engineering proteins with non-canonical amino acids. The re-coding with non-canonical amino acids opens a vast diversity of new chemical functionalities that are helpful, e.g., to enhance the design of enzymes and the domains of other proteins used in biotechnology and pharmacology, to in... More about this image found in Engineering proteins with non-canonical amino acids. The re-coding with non...
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Published: 21 September 2023
Figure 3 Membrane-less organelles for designing proteins with an expanded genetic code. A stop codon, inserted into a specific mRNA at a defined location, can be recoded to a sense codon, encoding a non-canonical amino acid. Besides the general translation machinery that includes the ribosome and ... More about this image found in Membrane-less organelles for designing proteins with an expanded genetic co...
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in From unique challenges to inspired solutions: how vector engineering makes in vivo gene therapy possible
> The Biochemist
Published: 24 August 2023
Figure 1 The expression cassette of an AAV vector containing viral sequences (inverted terminal repeats, ITR), regulatory sequences and a therapeutic coding sequence. More about this image found in The expression cassette of an AAV vector containing viral sequences (invert...
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in From unique challenges to inspired solutions: how vector engineering makes in vivo gene therapy possible
> The Biochemist
Published: 24 August 2023
Figure 2 Achieving specific expression in gene therapy via the use of tissue-specific promoters and miRNA target sequences. An artificial promoter (LP1) activates the therapeutic coding sequence in hepatocytes and a few other tissues, while another artificial hybrid promoter (MHCK7) drives activit... More about this image found in Achieving specific expression in gene therapy via the use of tissue-specifi...
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in Healing hearts: unlocking the potential of gene therapy in revolutionizing cardiovascular disease treatment
> The Biochemist
Published: 23 August 2023
Figure 1 Advances in gene therapy for cardiovascular disease: delivery methods, targets and disease processes (created with Biorender.com by Dr Georgios Krilis). More about this image found in Advances in gene therapy for cardiovascular disease: delivery methods, targ...
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Published: 21 August 2023
Figure 1 Following a DNA DSB, the MRN complex detects and holds together the two broken ends of the DNA molecule. MRN then acts as a platform for the recruitment and activation of ATM kinase, which amplifies and relays the signal onto p53. p53, along with other proteins, acts as a transcription fa... More about this image found in Following a DNA DSB, the MRN complex detects and holds together the two bro...
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Published: 21 August 2023
Figure 2 Checkpoint kinase pathway without functional ATM kinase. Loss of ATM kinase results in a breakdown in communication between the MRN complex and p53. Subsequently, downstream effectors cannot be regulated through this pathway, which leads to faulty repair of DNA DSBs and the symptoms of A-... More about this image found in Checkpoint kinase pathway without functional ATM kinase. Loss of ATM kinase...
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Published: 21 August 2023
Figure 3 Lentiviral vector production. A transgene is first cloned into a transfer plasmid in between viral cis -acting sequences. These are sequences needed for the packaging of the vector genome into lentiviral virions in producer cells (and later for reverse transcription and integration in tr... More about this image found in Lentiviral vector production. A transgene is first cloned into a transfer p...
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Published: 21 August 2023
Figure 4 Expression of survival motor neuron (SMN) genes. SMN is required for all cells to remain healthy, especially motor neurons. Individuals not affected by SMA have at least one functional copy of SMN1 . A paralogous gene SMN2 can also produce functional SMN, but at much reduced levels, ... More about this image found in Expression of survival motor neuron (SMN) genes. SMN is required for all ...
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