1. The metabolism of 2,6-dichlorobenzonitrile was studied in rabbits and rats. Oral administration caused an increased urinary excretion of glucuronides and ethereal sulphates. There was also an indication of mercapturic acid formation. 2,6-Dichloro-3-hydroxybenzonitrile and its 4-hydroxy analogue were identified as metabolites in the urine. A small amount of the unchanged substance was recovered from the faeces. 2. By using 2,6-dichlorobenzo[(14)C]nitrile the phenolic metabolites were determined quantitatively and some other possible metabolic routes were excluded. 3. Incubation of 2,6-dichlorobenzonitrile with enzyme preparations (papain and high-speed supernatant of rat-liver homogenate plus glutathione) gave no indications for a reaction with thiol compounds.
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Research Article| December 01 1966
Metabolism of the herbicide 2,6-dichlorobenzonitrile in rabbits and rats
Biochem J (1966) 101 (3): 698–706.
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JG Wit, H Van Genderen; Metabolism of the herbicide 2,6-dichlorobenzonitrile in rabbits and rats. Biochem J 1 December 1966; 101 (3): 698–706. doi: https://doi.org/10.1042/bj1010698
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