A strain of Aspergillus fumigatus Fresenius, isolated from spoiled hay, converts melilotic acid (o-hydroxyphenylpropionic acid) and o-coumaric acid into 4-hydroxycoumarin and dicoumarol. The sequence is shown to be melilotic acid (I) [Formula: see text] coumaric acid (IV) [Formula: see text] β-hydroxymelilotic acid (II) [Formula: see text] β-oxomelilotic acid (III) [Formula: see text] 4-hydroxycoumarin (VI), on the basis of (1) studies on the formation of postulated intermediates, (2) experiments with isotopically labelled materials and (3) sequential enzyme induction. In the presence of semicarbazide, o-coumaraldehyde is formed from o-coumaric acid: there is no evidence, however, that this lies on the normal metabolic pathway.
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Research Article| April 01 1970
The biosynthesis of 4-hydroxycoumarin and dicoumarol by Aspergillus fumigatus Fresenius
A. Bye ;
Biochem J (1970) 117 (2): 237–245.
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A. Bye, H. K. King; The biosynthesis of 4-hydroxycoumarin and dicoumarol by Aspergillus fumigatus Fresenius. Biochem J 1 April 1970; 117 (2): 237–245. doi: https://doi.org/10.1042/bj1170237
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