Two methylated derivatives of arginine were isolated from the encephalitogenic protein of myelin from the central nervous system. Evidence is presented for the proposed structures, ω-NN′-dimethylarginine and ω-N-monomethylarginine. In the encephalitogenic protein from human brain the proportion 1:6:10 for arginine:monomethylarginine:dimethylarginine residues was found to occur at position 107. Possible roles for the methylated arginine in conformational changes and altered ion-exchange behaviour are discussed.
Research Article| June 01 1971
Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin
G. S. Baldwin;
Biochem J (1971) 123 (1): 69–74.
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G. S. Baldwin, P. R. Carnegie; Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin. Biochem J 1 June 1971; 123 (1): 69–74. doi: https://doi.org/10.1042/bj1230069
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