The biosynthesis of the newly isolated polyamine, sym-homospermidine (NH2–[CH2]4–NH–[CH2]4 –NH2), was studied by using radioactive amino acids. Arginine was the most effective precursor, being about 10 times as active as ornithine. Unlabelled agmatine and putrescine markedly inhibited the incorporation of [14C]arginine into homospermidine. Similarly the incorporation of ornithine was inhibited by unlabelled arginine and putrescine. γ-Aminobutyraldehyde, the oxidation product of putrescine, was considered to be one of the intermediates in the biosynthesis of homospermidine. The biosynthesis may involve a Schiff-base formation of putrescine with γ-aminobutyraldehyde and subsequent reduction. A limited synthesis of spermidine also takes place under these conditions.
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Research Article| March 01 1972
Studies on the biosynthesis of sym-homospermidine in sandal (Santalum album L.)
Ramadasan Kuttan ;
Biochem J (1972) 127 (1): 61–67.
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Ramadasan Kuttan, A. N. Radhakrishnan; Studies on the biosynthesis of sym-homospermidine in sandal (Santalum album L.). Biochem J 1 March 1972; 127 (1): 61–67. doi: https://doi.org/10.1042/bj1270061
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