1. The specific radioactivity of plasma l-lactate and the incorporation of 14C into plasma d-glucose, liver glycogen and skeletal-muscle glycogen were measured as a function of time after the intraperitoneal injection of l-[U-14C]lactate into 2-, 10- and 30-day-old rats. 2. Between 15 and 60min after the injection of the l-[U-14C]lactate, the specific radioactivity of plasma lactate decreased with a half-life of 20–33min in animals at all three ages. 3. At all times after injection examined, the specific radioactivity of plasma glucose of the 2- and 10-day-old rats was at least fourfold greater than that of the 30-day-old rats. 4. Although 14C was incorporated into liver glycogen the amount incorporated was always less than 5% of that present in plasma glucose. 5. The results are discussed with reference to the factors that may influence the rate of incorporation of 14C into plasma glucose, and it is concluded that the rate of gluconeogenesis in the 2- and 10-day-old suckling rat is at least twice that of the weaned 30-day-old animal.
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April 1972
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Research Article|
April 01 1972
Gluconeogenesis from lactate in the developing rat. Studies in vivo
Richard G. Vernon;
Richard G. Vernon
1Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K.
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Deryck G. Walker
Deryck G. Walker
1Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K.
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Publisher: Portland Press Ltd
© 1972 London: The Biochemical Society
1972
Biochem J (1972) 127 (3): 531–537.
Citation
Richard G. Vernon, Deryck G. Walker; Gluconeogenesis from lactate in the developing rat. Studies in vivo. Biochem J 1 April 1972; 127 (3): 531–537. doi: https://doi.org/10.1042/bj1270531
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