A survey was made of the geometry of furanose rings in β-nucleotides and β-nucleosides (as monomers related to nucleic acids) for which structures have been determined by X-ray crystallography. Mean values, and estimated standard deviations from them, were calculated for bond-lengths, bond-angles and conformation-angles. For parameters with values dependent on ring-puckering, separate calculations were made for each ring type. (The rings are puckered in one of three conformations: C-2- or C-3-endo or C-3-exo; C-2-exo has not been observed.) The results were used to compute standard furanose rings with C-2-endo, C-3-endo and C-3-exo conformations for use in nucleic acid molecular model-building. The survey also showed that the only other conformation-angle in nucleotides dependent on the furanose ring conformation corresponds to the relative orientation of the purine (or pyrimidine) base and the ring.
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Research Article| November 01 1972
The dimensions and shapes of the furanose rings in nucleic acids
Biochem J (1972) 130 (2): 453–465.
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S. Arnott, D. W. L. Hukins; The dimensions and shapes of the furanose rings in nucleic acids. Biochem J 1 November 1972; 130 (2): 453–465. doi: https://doi.org/10.1042/bj1300453
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