1. [7α-3H1]- and [7β-3H1]-Cholesterol were synthesized by a modified method. 2. The stereochemistry of Δ7-bond formation during ecdysone and ecdysterone biosynthesis in the insect, Calliphora erythrocephala and the plants, Taxus baccata and Polypodium vulgare was investigated by using [4-14C,7α-3H1]cholesterol and [4-14C,7β-3H1]cholesterol. 3. In each case, the 7β hydrogen was stereospecifically eliminated. 4. The possible significance of the results is discussed in relation to double-bond formation in other systems and the stage at which the Δ7 bond is introduced during ecdysone biosynthesis.
The stereochemistry of hydrogen elimination from C-7 during biosynthesis of ecdysones in insects and plants
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I. F. Cook, J. G. Lloyd-Jones, H. H. Rees, T. W. Goodwin; The stereochemistry of hydrogen elimination from C-7 during biosynthesis of ecdysones in insects and plants. Biochem J 15 September 1973; 136 (1): 135–145. doi: https://doi.org/10.1042/bj1360135
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