1. Adrenergic agonists provoke a marked increase in labelling of phosphatidylinositol in fragments of rat parotid gland. 2. Adrenaline and phenylephrine (an adrenergic α-agonist) are effective stimulants, but isoprenaline (an adrenergic β-agonist) is relatively ineffective. 3. The response evoked by phenylephrine or adrenaline is prevented by prior incubation of the tissue with phenoxybenzamine (an α-receptor blocking agent), but not by prior incubation with pindolol (a β-receptor blocking agent). 4. Adrenergic stimulation of phosphatidylinositol metabolism in parotid gland is therefore mediated through α-receptors, in common with the adrenaline-induced K+ efflux. It is not linked to enzyme secretion, which is triggered by stimulation of β-receptors. 5. It is suggested that the stimulation of phospholipid metabolism that occurs in several other tissues in the presence of adrenaline or noradrenaline may also involve α-receptors.
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Research Article| January 01 1974
Enhanced phosphatidylinositol labelling in rat parotid fragments exposed to α-adrenergic stimulation
Robert H. Michell;
Biochem J (1974) 138 (1): 47–52.
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Robert H. Michell, Lynne M. Jones; Enhanced phosphatidylinositol labelling in rat parotid fragments exposed to α-adrenergic stimulation. Biochem J 1 January 1974; 138 (1): 47–52. doi: https://doi.org/10.1042/bj1380047
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