At concentrations of 2mM and above hydroxypyruvate produced no glucose with isolated rat liver cells, although it was rapidly utilized. At a lower concentration of hydroxypyruvate or in the presence of substrates which generate reducing equivalents (ethanol or butyrate), appreciable amounts of glucose were formed from hydroxypyruvate. A possible explanation for this phenomenon is discussed.
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Research Article| January 01 1975
Hydroxypyruvate as a gluconeogenic substrate in rat hepatocytes*
Biochem J (1975) 146 (1): 277–279.
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D H Williamson, E V Ellington; Hydroxypyruvate as a gluconeogenic substrate in rat hepatocytes. Biochem J 1 January 1975; 146 (1): 277–279. doi: https://doi.org/10.1042/bj1460277
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