1. Perfusion of livers with whole blood containing carboxyhaemoglobin decreased hepatic O2 consumption and triglyceride secretion and raised free fatty acid oxidation. 2. Perfusion with [14C]carboxyhaemoglobin indicated that there was negligible hepatic uptake of 14CO. 3. The observations appear to be due to a decrease in O2 consumption rather than to specific effects of carboxyhaemoglobin.

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