1. Rats trained on a controlled lighting and feeding schedule were subjected to partial hepatectomy or sham operation. 2. After a large period of about 6h the activity of UDP-galactose 4-epimerase increased threefold, reaching a maximum 4 days after partial hepatectomy, and returned to normal values within a fortnight. 3. The enzyme pattern of the UDP-galactose-glycoprotein galactosyltransferase was biphasic, one peak appearing at 20 h, the second at 72 h after partial hepatectomy. 4. The rise in enzyme activities could be blocked by the injection of actinomycin D, and the Km values for UDP-glucose and UDP-galactose were nearly identical in regenerating and adult liver. It is therefore concluded that the increase in enzyme activity is due to synthesis de novo of enzyme protein.
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Research Article| January 15 1976
Galactose metabolism in regenerating rat liver
Biochem J (1976) 154 (1): 141–147.
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C H Bauer, B F Hassels, W G Reutter; Galactose metabolism in regenerating rat liver. Biochem J 15 January 1976; 154 (1): 141–147. doi: https://doi.org/10.1042/bj1540141
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