Membranes from human O Rhesus-positive erythrocyte ‘ghosts’ were tested in vitro for their ability to digest their own glycoproteins. ‘Ghost’ membranes incubated in Tris/HCl buffer, pH 7.4, release a sialoglycopeptide, which contains glucosamine, galactosamine, galactose and mainly polar amino acids. Chemical composition, molecular size and aggregation properties suggest that this glycopeptide may be a fragment of glycophorin.
Identification of a sialoglycopeptide released by self-digestion from human erythrocyte membranes
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A Brovelli, G Pallavicini, F Sinigaglia, C L Balduini, C Balduini; Identification of a sialoglycopeptide released by self-digestion from human erythrocyte membranes. Biochem J 15 August 1976; 158 (2): 497–500. doi: https://doi.org/10.1042/bj1580497
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