1. Incubation of submaxillary-gland slices with isoproterenol, a β-adrenergic agonist, stimulated glucose removal by 41% and decreased tissue [glucose 6-phosphate] by 50%. Propranolol blocked these effects of isoproterenol. 2. Phenylephrine, an α-adrenergic agonist, stimulated glucose removal by 35% and decreased tissue [glucose 6-phosphate] by 75%. In addition, phenylephrine also completely overcame the inhibition of pyruvate removal caused by acetoacetate metabolism and decreased tissue [atp] by 45%. Phentolamine blocked the effects of phenylephrine. 3. In contrast with β-adrenergic stimulation, α-adrenergic stimulation required exogenous Ca2+. 4. These results explain the different metabolic responses of the submaxillary gland to adrenaline in the presence and absence of exogenous Ca2+.
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Research Article| December 15 1976
Metabolic effect of α-and the β-adrenergic stimulation of rat submaxillary gland in vitro
Biochem J (1976) 160 (3): 597–601.
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M P Thompson, D H Williamson; Metabolic effect of α-and the β-adrenergic stimulation of rat submaxillary gland in vitro. Biochem J 15 December 1976; 160 (3): 597–601. doi: https://doi.org/10.1042/bj1600597
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