Cobalt inhibits liver haem synthesis in vivo by acting at least two different sites in the biosynthetic pathway: (1) synthesis of 5-aminolaevulinate and (2) conversion of 5-amino-laevulinate into haem. The first effect is largely, if not entirely, due to inhibition of the activity of 5-aminolaevulinate synthase, rather than to inhibition of the formation of the enzyme. The second effect results from diversion of 5-aminolaevulinate into an unidentified liver pool with solubility properties similar to those of cobalt protoporphyrin.
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Research Article| January 15 1977
Inhibition of haem synthesis caused by cobalt in rat liver. Evidence for two different sites of action
Biochem J (1977) 162 (1): 213–216.
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F De Matteis, A H Gibbs; Inhibition of haem synthesis caused by cobalt in rat liver. Evidence for two different sites of action. Biochem J 15 January 1977; 162 (1): 213–216. doi: https://doi.org/10.1042/bj1620213
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