After exchange with [14C]cholesterol-labelled plasma lipoproteins for 0.5-4h, erythrocytes were extracted with bile-salt solutions. The extracted cholesterol (mainly from the outside of the erythrocyte membrane) had the same specific radioactivity as the residual sterol. Thus cholesterol equilibrates rapidly (half-time less than 1 h) between the two sides of the membrane.
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Research Article| December 15 1977
Transmembrane migration (‘flip-flop’) of cholesterol in erythrocyte membranes
Biochem J (1977) 168 (3): 575–577.
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C J Kirby, C Green; Transmembrane migration (‘flip-flop’) of cholesterol in erythrocyte membranes. Biochem J 15 December 1977; 168 (3): 575–577. doi: https://doi.org/10.1042/bj1680575
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