The beta-subunit of human chorionic gonadotropin, purified immunochemically to eliminate undissociated human chorionic gonadotropin, induced testosterone production by mouse Leydig cells at concentrations 400-fold higher than human chorionic gonadotropin. Steroidogenesis was also stimulated by a synthetic fragment of the beta-subunit of human chorionic gonadotropin conforming to the peptide sequence residues 39–71, whereas peptide sequence residues 39–56 and three C-terminal fragments (residues 115–145, 111–145 and 101–145) failed to cause steroidogenesis. These studies suggest the presence in the beta-subunit of human chorionic gonadotropin of determinants recognized by the tissue receptors, a part of these determinants residing between amino acid residues 57–71.
Recognition of the Beta-subunit of human chorionic gonadotropin and sub-determinants by target tissue receptors
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S Ramakrishnan, C Das, G P Talwar; Recognition of the Beta-subunit of human chorionic gonadotropin and sub-determinants by target tissue receptors. Biochem J 15 November 1978; 176 (2): 599–602. doi: https://doi.org/10.1042/bj1760599
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