The inactivation of beta-lactamase I by preparations of 6alpha-bromopenicillanic acid showed unexpected kinetic features that indicated that the active species was the 6beta-epimer. Samples containing 6beta-bromopenicillanic acid have been synthesized and shown to inactivate the enzyme in a rapid stoicheiometric reaction.
Research Article| January 01 1979
6 β-Bromopenicillanic acid inactivates β-lactamase I
V Knott-Hunziker; ; ;
Biochem J (1979) 177 (1): 365-367.
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V Knott-Hunziker, B S Orlek, P G Sammes, S G Waley; 6 β-Bromopenicillanic acid inactivates β-lactamase I. Biochem J 1 January 1979; 177 (1): 365–367. doi: https://doi.org/10.1042/bj1770365
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