Glutamine synthetase activity in a cytosol extract of liver was inhibited non-competitively by Mn2+ ions. The apparent Ki for Mn2” in the presence of phosphate was 8 micro M. Inhibition of glutamine synthetase by intracellular Mn2+ may contribute to the very low rates of glutamine synthesis observed in perfused liver and isolated hepatocytes.
Skip Nav Destination
Research Article| November 15 1979
Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver
Biochem J (1979) 184 (2): 477–480.
- Views Icon Views
- Share Icon Share
S K Joseph, N M Bradford, J D McGivan; Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver. Biochem J 15 November 1979; 184 (2): 477–480. doi: https://doi.org/10.1042/bj1840477
Download citation file: