DNA was alkylated in neutral solution at 37 degrees C with 1,2:5,6-dianhydrogalactitol and hydrolysed to yield two principal products, identified as 7-galactitylguanine and 1,6-dideoxy-1,6-di(guanin-7-yl)galactitol. The reaction products were separated by chromatography on Sephadex G-10 and Dowex 50 (H+ form). The two compounds were also obtained by reaction between dianhydrogalactitol and guanosine in acetic acid. The products were characterized from their u.v.-spectral data by comparison with those of the 7-alkylguanines and were also identified by mass spectrometry.
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Research Article| March 01 1980
Alkylation by 1,2:5,6-dianhydrogalactitol of deoxyribonucleic acid and guanosine
Biochem J (1980) 185 (3): 659–666.
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E Institóris, J Tamás; Alkylation by 1,2:5,6-dianhydrogalactitol of deoxyribonucleic acid and guanosine. Biochem J 1 March 1980; 185 (3): 659–666. doi: https://doi.org/10.1042/bj1850659
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