In a search for new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, it was found that various benzamides substituted in the 3-position were the most inhibitory compounds found to date. Two of the benzamides, 3-aminobenzamide and 3-methoxybenzamide, were found to be competitive inhibitors, with Ki values or less than 2 microM.
Research Article| March 01 1980
Novel inhibitors of poly(ADP-ribose) synthetase
Biochem J (1980) 185 (3): 775-777.
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M R Purnell, W J Whish; Novel inhibitors of poly(ADP-ribose) synthetase. Biochem J 1 March 1980; 185 (3): 775–777. doi: https://doi.org/10.1042/bj1850775
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