Interaction between 6-mercaptopurine, Cu2+ and the enzyme xanthine oxidase (EC 18.104.22.168.) was examined. Whereas Cu2+ was found to inhibit the enzyme, 6-mercaptopurine could protect as well as reverse the enzyme inhibition produced by the metal ion. The formation of a complex between 6-mercaptopurine and Cu2+ seems to be responsible for the observed effect. Job's [(1928) Ann. Chem. 9, 113] method has shown the composition of the complex to be 1:1. The apparent stability constant (log K value), as determined by Subhrama Rao & Raghav Rao's [(1955) J. Sci. Chem. Ind. Res. 143, 278], method is found to be 6.74. It is suggested that the formation of a stable complex between 6-mercaptopurine molecules and Cu2+ may be an additional mechanism of action of 6-mercaptopurine, particularly with reference to its anti-inflammatory properties.
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Research Article| March 01 1981
Studies on the mechanism of action of 6-mercaptopurine. Interaction with copper and xanthine oxidase
Biochem J (1981) 193 (3): 799–803.
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U Kela, R Vijayvargiya; Studies on the mechanism of action of 6-mercaptopurine. Interaction with copper and xanthine oxidase. Biochem J 1 March 1981; 193 (3): 799–803. doi: https://doi.org/10.1042/bj1930799
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