The addition of 1 microM-vasopressin or -angiotensin to isolated rat hepatocytes induced a fast transient inhibition of the rate of incorporation of [Me-3H]choline into phosphatidylcholine. The cationophore A23187 induced a similar inhibition of phosphatidylcholine synthesis. The addition of micromolar Ca2+ to rat liver microsomes inhibited the activity of CDP-choline: 1,2-diacylglycerol cholinephosphotransferase. This inhibition is due a decrease in the Vmax. of the enzyme without affecting the Km for CDP-choline. It is concluded that Ca2+ regulates phosphatidylcholine synthesis in rat liver.
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Research Article| November 15 1982
Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes
Biochem J (1982) 208 (2): 453–457.
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S Alemany, I Varela, J M Mato; Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes. Biochem J 15 November 1982; 208 (2): 453–457. doi: https://doi.org/10.1042/bj2080453
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