The accumulation of cystine in cystinotic fibroblasts from free and protein-linked cystine has been investigated. Cystine is not accumulated from cysteine but is readily accumulated from cystine. The accumulation from free cystine does not occur as a result of pinocytosis or from the degradation of a rapidly metabolized protein pool. Further studies of the degradation of disulphide-containing proteins by these cells may aid understanding of the mechanisms of proteolysis.
Research Article| December 15 1982
Cystine accumulation in cystinotic fibroblasts from free and protein-linked cystine but not cysteine
Jess G. Thoene;
Biochem J (1982) 208 (3): 823–830.
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Jess G. Thoene, Rosemary M. Lemons; Cystine accumulation in cystinotic fibroblasts from free and protein-linked cystine but not cysteine. Biochem J 15 December 1982; 208 (3): 823–830. doi: https://doi.org/10.1042/bj2080823
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