The effects of glucose on phosphorylase and glycogen synthase were investigated in hepatocytes isolated from acutely (40 h) and chronically (90 h) alloxan-diabetic rats. The glucose-induced inactivation of phosphorylase proceeded normally in all conditions. The ensuing activation of glycogen synthase was slightly blunted in acute diabetes, but became virtually absent in 72 h diabetes of similar severity. In hepatocytes from rats with various degrees of chronic diabetes, the maximal activation of glycogen synthase (at 60 mM-glucose) was inversely correlated with the plasma glucose concentration.
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Research Article| March 15 1983
Effects of glucose on phosphorylase and glycogen synthase in hepatocytes from diabetic rats
Biochem J (1983) 210 (3): 783–787.
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M Bollen, L Hue, W Stalmans; Effects of glucose on phosphorylase and glycogen synthase in hepatocytes from diabetic rats. Biochem J 15 March 1983; 210 (3): 783–787. doi: https://doi.org/10.1042/bj2100783
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