Denatured or modified proteins (including albumin and low-density lipoprotein) are catabolized in vitro via scavenger receptors. We have studied the distribution of formaldehyde-denatured albumin in rat liver cells after intravenous injection of tracer doses of the protein. At 12 min after injection, most of the formaldehyde-denatured albumin (about 70% of the injected dose) was recovered in liver endothelial cells. Furthermore, isolated liver endothelial cells in suspension and in surface culture took up formaldehyde-denatured albumin by receptor-mediated endocytosis. Our data indicate that the scavenger receptor in liver is mainly located on the endothelial cells. Implications for the catabolism of low-density lipoproteins are discussed.
Research Article| February 15 1984
Endocytosis of formaldehyde-treated serum albumin via scavenger pathway in liver endothelial cells
Biochem J (1984) 218 (1): 81–86.
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R Blomhoff, W Eskild, T Berg; Endocytosis of formaldehyde-treated serum albumin via scavenger pathway in liver endothelial cells. Biochem J 15 February 1984; 218 (1): 81–86. doi: https://doi.org/10.1042/bj2180081
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