The rate of tryptophan metabolism in isolated liver cells from animals fed on a high-leucine diet was greater than for cells from control animals. Leucine inhibited tryptophan metabolism and tryptophan uptake in isolated liver cells, probably by competing for membrane transport. Leucine had no effect on tryptophan 2,3-dioxygenase in vitro. 4-Methyl-2-oxovalerate increased tryptophan oxidation in incubations containing albumin, by displacing bound tryptophan and increasing the availability of the amino acid to the cell. The results suggest that, under extreme conditions, when the availability of tryptophan is low, leucine may be pellagragenic.
Skip Nav Destination
Research Article| January 15 1985
Leucine and tryptophan metabolism in rats
Biochem J (1985) 225 (2): 277–281.
M Salter, D A Bender, C I Pogson; Leucine and tryptophan metabolism in rats. Biochem J 15 January 1985; 225 (2): 277–281. doi: https://doi.org/10.1042/bj2250277
Download citation file:
Don't already have an account? Register
Get Access To This Article
Buy This Article