Luminol-mediated chemiluminescence in neutrophils is stimulated by Sendai virus and by influenza virus; Lettré cells also exhibit chemiluminescence (less than 10% of that of neutrophils), which is stimulated by Sendai virus and by influenza virus. Virally induced permeability changes are not responsible for chemiluminescence, since (i) extracellular Ca2+ inhibits permeability changes but stimulates chemiluminescence, and (ii) influenza virus, which induces permeability changes at pH 5.3 but not at pH 7.4, induces chemiluminescence at either pH. Other agents [zymosan, N-formyl-L-methionyl-L-leucyl-L-phenylalanine, 4-phorbol 12-myristate 13-acetate (phorbol ester), A23187] likewise induce chemiluminescence in the absence of permeability changes.
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Research Article| April 01 1985
Chemiluminescence in neutrophils and Lettré cells induced by myxoviruses
C L Bashford ;
Biochem J (1985) 227 (1): 99–104.
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S Mehta, C L Bashford, P Knox, C A Pasternak; Chemiluminescence in neutrophils and Lettré cells induced by myxoviruses. Biochem J 1 April 1985; 227 (1): 99–104. doi: https://doi.org/10.1042/bj2270099
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