Purinergic agonists cause a dose-dependent activation of glycogen phosphorylase in isolated rat hepatocytes. Half-maximally effective concentrations are 5 × 10(-7)M for ATP, 2 × 10(-6)M for ADP, and about 5 × 10(-5) M for AMP and adenosine. This potency series indicates the presence of P2-purinergic receptors. The mode of action of ATP appears to be identical with that of the Ca2+-dependent glycogenolytic hormones angiotensin, vasopressin and alpha 1-adrenergic agonists. (1) They all require Ca2+ for phosphorylase activation; (2) they do not increase cyclic AMP levels; (3) they are susceptible to heterologous desensitization by vasopressin and phenylephrine; (4) they lower cyclic AMP concentrations in hepatocytes stimulated by glucagon, most probably mediated by an enhanced phosphodiesterase activity.
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Research Article| November 01 1985
P2-purinergic control of liver glycogenolysis
Biochem J (1985) 231 (3): 797–799.
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S Keppens, H De Wulf; P2-purinergic control of liver glycogenolysis. Biochem J 1 November 1985; 231 (3): 797–799. doi: https://doi.org/10.1042/bj2310797
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