Several alpha-oxohydroxy heteroaromatic chelators have been shown to mobilize iron from horse spleen ferritin. Although the reactions were slow, taking up to 3 days to reach completion, the amounts of iron mobilized were higher than those reported for other chelators. These results increase the prospects for the clinical use of alpha-oxohydroxy chelators in the treatment of iron overload.
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G J Kontoghiorghes; Iron mobilization from ferritin using α-oxohydroxy heteroaromatic chelators. Biochem J 1 January 1986; 233 (1): 299–302. doi: https://doi.org/10.1042/bj2330299
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