Platelet factor 4 is a small protein (Mr 7756) from the alpha-granules of blood platelets which binds strongly to and neutralizes the anticoagulant properties of heparin. From an analysis of X-ray crystallographic data a model for the binding of platelet factor 4 to heparin is proposed.
Research Article| March 01 1986
Binding of heparin to human platelet factor 4
Biochem J (1986) 234 (2): 485–488.
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S W Cowan, E N Bakshi, K J Machin, N W Isaacs; Binding of heparin to human platelet factor 4. Biochem J 1 March 1986; 234 (2): 485–488. doi: https://doi.org/10.1042/bj2340485
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