Sickle erythrocytes and their membranes are susceptible to endogenous free-radical-mediated oxidative damage which correlates with the proportion of irreversibly sickled cells. The suppression of incubation-induced oxidative stress by antioxidants, free radical scavengers and an iron chelator suggest that oxidation products of membrane-bound haemoglobin contribute towards the pathology of the disease.
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Research Article| July 01 1986
Sickle cell membranes and oxidative damage
Biochem J (1986) 237 (1): 265–269.
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C Rice-Evans, S C Omorphos, E Baysal; Sickle cell membranes and oxidative damage. Biochem J 1 July 1986; 237 (1): 265–269. doi: https://doi.org/10.1042/bj2370265
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