Human genomic clones containing parts of the lactate dehydrogenase B (LDH-B) gene (approx. 25 kb in length) were isolated and characterized. The protein-coding sequence of human LDH-B gene is interrupted by six introns at codons nos. 42-43, 82, 140, 198, 237 and 278-279, and the positions of these introns are homologous to those of LDH-A genes from man and mouse. The 5' non-coding region of human LDH-B gene is interrupted by an intron six nucleotide residues upstream of the ATG translation-initiation site, whereas those of human and mouse LDH-A genes are interrupted at 24 nucleotide residues 5' to the ATG initiation codon. As is the case of LDH-A genes from man and mouse, there is no intron in the 3' non-coding region of human LDH-B gene.
Research Article| February 01 1989
Structure of the human lactate dehydrogenase B gene
Biochem J (1989) 257 (3): 921-924.
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T Takeno, S S L Li; Structure of the human lactate dehydrogenase B gene. Biochem J 1 February 1989; 257 (3): 921–924. doi: https://doi.org/10.1042/bj2570921
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