After an intraperitoneal injection of 100 mumol of methionine to rats, there is rapid oxidation of the methyl group of hepatic 5-methyltetrahydrofolate to formate and CO2. Recovery of the methylfolate level starts 2.5 h after the methionine injection, when the hepatic methionine level and the S-adenosylmethionine/S-adenosylhomocysteine ratio have returned to baseline values. S-Adenosylmethionine concentration is still elevated at this time.
Research Article| March 01 1989
Regulation of 5-methyltetrahydrofolate synthesis
Biochem J (1989) 258 (2): 611–612.
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M Lumb, T Bottiglieri, R Deacon, J Perry, I Chanarin; Regulation of 5-methyltetrahydrofolate synthesis. Biochem J 1 March 1989; 258 (2): 611–612. doi: https://doi.org/10.1042/bj2580611
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