In rats with chronic dietary iron overload, a higher amount of liver ferritin L-subunit mRNA was found mainly engaged on polysomes, whereas in control rats ferritin L-subunit mRNA molecules were largely stored in ribonucleoprotein particles. On the other hand, ferritin H-subunit mRNA was unchanged by chronic iron load and remained in the inactive cytoplasmic pool. In agreement with previous reports, in rats acutely treated with parenteral iron, only the ferritin L-subunit mRNA increased in amount, whereas both ferritin subunit mRNAs shifted to polysomes. This may indicate that, whereas in acute iron overload the hepatocyte operates a translation shift of both ferritin mRNAs to confront rapidly the abrupt entry of iron into the cell, during chronic iron overload it responds to the slow iron influx by translating a greater amount of L-subunit mRNA to synthesize isoferritins more suitable for long-term iron storage.
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December 1989
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Research Article|
December 15 1989
Translational regulation of ferritin synthesis in rat liver. Effects of chronic dietary iron overload
G Cairo;
G Cairo
*Istituto di Patologia Generale, Centro di Studio sulla Patologia Cellulare CNR, Via Mangiagalli 31, 20133 Milano
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L Tacchini;
L Tacchini
*Istituto di Patologia Generale, Centro di Studio sulla Patologia Cellulare CNR, Via Mangiagalli 31, 20133 Milano
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L Schiaffonati;
L Schiaffonati
*Istituto di Patologia Generale, Centro di Studio sulla Patologia Cellulare CNR, Via Mangiagalli 31, 20133 Milano
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E Rappocciolo;
E Rappocciolo
*Istituto di Patologia Generale, Centro di Studio sulla Patologia Cellulare CNR, Via Mangiagalli 31, 20133 Milano
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E Ventura;
E Ventura
†Clinica Medica III, Universita di Modena, Via Del Pozzo 71, 41100 Modena, Italy
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A Pietrangelo
A Pietrangelo
*Istituto di Patologia Generale, Centro di Studio sulla Patologia Cellulare CNR, Via Mangiagalli 31, 20133 Milano
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Publisher: Portland Press Ltd
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 1989 London: The Biochemical Society
1989
Biochem J (1989) 264 (3): 925–928.
Citation
G Cairo, L Tacchini, L Schiaffonati, E Rappocciolo, E Ventura, A Pietrangelo; Translational regulation of ferritin synthesis in rat liver. Effects of chronic dietary iron overload. Biochem J 15 December 1989; 264 (3): 925–928. doi: https://doi.org/10.1042/bj2640925
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