The increased activity of pyruvate dehydrogenase (PDH) kinase induced in hearts of rats by starvation for 48 h was maintained following preparation of cardiac myocytes, and it was also maintained, though at a decreased level, after 25 h of culture in medium 199. This loss of PDH kinase activity was not prevented by n-octanoate, dibutyryl cyclic AMP or glucagon. The PDH kinase activity of myocytes from fed rats was increased to that of starved rats after 25 h of culture with n-octanoate, dibutyryl cyclic AMP or both agents together.
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Research Article| April 01 1990
Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat cardiac myocytes
D R Marchington;
A L Kerbey;
Biochem J (1990) 267 (1): 245–247.
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D R Marchington, A L Kerbey, P J Randle; Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat cardiac myocytes. Biochem J 1 April 1990; 267 (1): 245–247. doi: https://doi.org/10.1042/bj2670245
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