Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation.
Research Article| September 15 1990
Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat
R G Knowles;
Biochem J (1990) 270 (3): 833–836.
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R G Knowles, M Merrett, M Salter, S Moncada; Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem J 15 September 1990; 270 (3): 833–836. doi: https://doi.org/10.1042/bj2700833
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