We have found that purified human peripheral-blood granulocytes express constitutively significant levels of proto-oncogenes c-jun, jun B and jun D mRNA. Upon functional activation of granulocytes by 4 beta-phorbol 12-myristate 13-acetate (PMA), the levels of c-jun, jun B and jun D transcripts were increased. The three jun genes showed a similar time course in their induction by PMA, maximal mRNA levels being reached after 60 min of induction. These results suggest that expression of c-jun, jun B and jun D genes might be involved in terminal granulocyte differentiation or in regulating granulocyte functionality.
Research Article| January 15 1991
Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes
M J Vaquerizo;
Biochem J (1991) 273 (2): 477–479.
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F Mollinedo, M J Vaquerizo, J R Naranjo; Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes. Biochem J 15 January 1991; 273 (2): 477–479. doi: https://doi.org/10.1042/bj2730477
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